Monday, January 13, 2014

The use of Ivermectin


Ivermectin is used to treat strongyloidiasis (threadworm; infection with a type of roundworm that enters the body through the skin, moves through the airways and lives in the intestines). Ivermectin is also used to control onchocerciasis (river blindness; infection with a type of roundworm that may cause rash, bumps under the skin, and vision problems including vision loss or blindness). Ivermectin is in a class of medications called anthelmintics. It treats strongyloidosis by killing the worms in the intestines. It treats onchocerciasis by killing the developing worms. Ivermectin does not kill the adult worms that cause onchocerciasis and therefore it will not cure this type of infection.

Ivermectin is a broad-spectrum antiparasitic agent, traditionally against worms.
It is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations such as strongyloidiasis, ascariasis, trichuriasis, filariasis, enterobiasis, and some epidermal parasitic skin diseases, including scabies.
Ivermectin, under the brand name Mectizan, is currently being used to help eliminate river blindness  in the Americas, and to stop transmission of lymphatic filariasis and onchocerciasis around the world. Currently, large amounts of ivermectin are donated by Merck to fight river blindness in countries unable to afford the drug. The disease is endemic in 30 African countries, six Latin American countries, and Yemen, according to studies conducted by the World Health Organization.The drug rapidly kills microfilariae, but not the adult worms. A single oral dose of Ivermectin  taken annually for the 10- to 15-year lifespan of the adult worms, is all that is needed to protect the individual from onchocerciasis.

CAS:70288-86-7
Specification: EP5
Molecular Formula:C48H74O14
Molecular Weight:875.09g/mol

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