about Prostaglandin E1

Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil, is a prostaglandin. It is a drug used in the treatment of erectile dysfunction[2] and has vasodilatory properties. In healthy humans, Prostaglandin E1 is biosynthesized "on demand" at its intended site of action from Dihomo-γ-linolenic_acid. Alprostadil is also used in maintaining a patent ductus arteriosus in newborns. This is primarily useful when there is threat of premature closure of the ductus arteriosus in an infant with ductal-dependent congenital heart disease, including cyanotic lesions  and acyanotic lesions。Alprostadil is also used for critical limb ischemia. It increases blood flow by peripheral vasodilation within 5 minutes and induces angiogenesis. It is most effective when the ankle pressure is at least 30 mmHg and at least one tibial artery is patent.More about Prostaglandin E1