About Perindopril Erbumine

Perindopril  is used to treat high blood pressure, heart failure or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (trade name Aceon). According to the Australian government's Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However the dose prescribed to achieve the same effect will differ due to different molecular weights for the two forms.For Perindopril as treatment for hypertension, the initiation dose is 5 mg perindopril arginine  once daily, then the dose may be increased to 10 mg perindopril arginine  after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease.
The Anglo-Scandinavian Cardiac Outcomes Trial showed the benefits of taking the two drugs Perindopril and Amlodipine together. The 9000 British patients aged 40 to 79 were involved in the five-year trial. Half were given the new drug combination, the rest were given traditional drugs. Perindopril and Amlodipine were found to be so effective that the trial was stopped early so that all patients could receive the combination.
CAS:107133-36-8
Molecular Formula:  C19H32N2O5.C4H11N
Formula Weight:441.609