Wednesday, January 15, 2014

Alpha-Chloralose


Alpha-Chloralose is an avicide, rodenticide used to kill mice in temperatures below 15 °C, and bird repellent. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.Chemically, it is a chlorinated acetal derivative of glucose.It is listed in Annex I of Directive 67/548/EEC with the classification Harmful (Xn).
Alpha-chloralose (AC) is an anaesthetic compound also used as a rodenticide, and has dose-dependent central nervous system mixed effects of excitation and depression. The objectives of this study were to detail the clinical and clinicopathological characteristics, as well as the treatment and prognosis, of AC toxicosis in dogs and cats. Medical records were retrospectively reviewed for AC poisoning between the years 1989 and 2004, and 33 dogs and 13 cats were included in the study. The most common clinical signs were seizures, muscle tremor, hyperaesthesia, hypothermia, salivation, myosis, stupor, coma and ataxia.
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