about Estradiol

Estradiol is a sex hormone. Estradiol is the predominant sex hormone present in females; however, it is present in males, although at lower levels, as well. It represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including the bones.
During the reproductive years, most estradiol in women is produced by the granulosa cells of the ovaries by the aromatization of androstenedione to estrone, followed by conversion of estrone to estradiol by 17β-hydroxysteroid dehydrogenase. Smaller amounts of estradiol are also produced by the adrenal cortex, and (in men), by the testes.
Estradiol is not produced in the gonads only: In both sexes, testosterone is converted by aromatization to estradiol. In particular, fat cells produce active precursors to estradiol, and will continue to do so even after menopause.
Estradiol is also produced in the brain and in arterial walls, though it cannot be readily transferred from the circulatory system into the brain. However, as one of the two active metabolites of testosterone in males , it can be produced from this hormone within the brain.

CAS:50-28-2
Specification:96 hole/box
Molecular Formula: C18H24O2
Molecular Weight: 272.38 g/mol