The information of Sulfonamide

Chinese name: sulfa
Synonyms: 4 – amino-benzene sulfonamide; crystalline sulfonamides; dapsone sulfa; sulfanilamide; sulfonamides; Dapsone sulfonamide; 1 – methyl – 4 – ethoxycarbonyl – 5 – sulfonamido pyrazole; amino-benzene sulfonamides
English name: Sulfanilamide
Synonyms: 1162 the F; 1162f; 4 – (Aminosulfonyl) aniline; 4-amino-benzenesulfonamid; 4-Aminophenylsulfonamide; 4-Sulfamoylaniline; A-349; Albexan
CAS No.: 63-74-1
MF: C6H8N2O2S
Molecular weight: 172.2
Product Features
Sulfonamides, also known as amino benzene sulfonamide, sulfonamide, sulfonamide aniline, aniline sulfonamide. Precipitation from ethanol aqueous solution for the white leaf-shaped crystals or crystalline powder, odorless, taste bitter then sweet, the case of light color. Relative molecular mass of 172.22. The relative density of 1.08. The melting point of 165 ~ 166 ℃. Soluble in benzene, ether, chloroform, soluble in water (g / l): when 477 at 17.0,60 ℃ 7.5,40 ° C 2.6,25 ° C 10 ° C 40.0,100 ℃, soluble in ethanol, each 37ml ethanol soluble 1g, 1g per 5ml acetone soluble, soluble in glycerol, propylene glycol, soluble in hydrochloric acid and sodium hydroxide (potassium) solution, the the sulfa aqueous solution of litmus paper was neutral, 0.5% aqueous solution of pH = 5.8 ~ 6.1 . Light colors become darker. Human sulfa large doses, can cause nausea, vomiting, diarrhea, affect the liver, kidney, can also cause tinnitus, dizziness, headache, or even a variety of neurological symptoms until death. The dog oral LD50 of 2000mg/kg.
[Pharmacodynamic] mechanism of action is to interfere with pathogenic microorganisms required for nucleic acid synthesis, causes the bacteria to the lack of nutrition and stop the growth, development and reproduction. Inhibited and killed hemolytic streptococcus, staphylococcus, and meningococcal.
Pharmacokinetics oral easily absorbed from the gastrointestinal tract, the body and widely spread, can penetrate the blood-brain barrier into the brain tissue, and can penetrate the placental barrier into the fetus. Faster excretion, mainly as metabolites excreted from the kidneys.
The clinical application] for the hemolytic streptococcus, Staphylococcus aureus caused by trauma, infection, and local wound infection.
[Uses]This product is sulfa drug toxicity is low, babies, pregnant women, pregnant women and during menstruation can be applied, but not large doses. Hemolytic streptococcal infection (erysipelas, puerperal fever, tonsillitis), urinary tract infections (gonorrhea) and so effective; also the synthesis intermediates of other sulfa drugs (such as Sulfanilamide sulfamethazine and sulfamethoxazole trimethoprim triazine ).
Read more:Sulfonamide for sale