Tuesday, December 31, 2013

What is Gemcitabine ?


Gemcitabine is a nucleoside analog used as chemotherapy. Gemcitabine HCL is a chemotherapy drug that is given as a treatment for some types of cancer. It is most commonly used to treat non-small cell lung cancer, pancreatic, bladder and breast cancer. Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in esophageal cancer, and is used experimentally in lymphomas and various other tumor types. Gemcitabine represents an advance in pancreatic cancer care[citation needed]. It is also not as debilitating as some other forms of chemotherapy.
A study reported in the Journal of the American Medical Association in 2007 suggested that gemcitabine showed benefit in patients with pancreatic cancer who were felt to have successful tumor resections.
CAS:12111-03-9
Molecular Formula:C9H11F2N3O4.HCl
Molecular Weight:299.66

What is rifampicin ?

Rifampicin or rifampin is a bactericidal antibiotic drug of the rifamycin group.It is a semisynthetic compound derived from Amycolatopsis rifamycinica.Rifampicin was introduced in 1967, as a major addition to the cocktail-drug treatment of tuberculosis and inactive meningitis, along with isoniazid, ethambutol, pyrazinamide and streptomycin. Rifampicin is an intensely red solid, and the small fraction which reaches body fluids is known for imparting a harmless red-orange color to the urine  of users, for a few hours after a dose. Maximal concentrations in the blood are decreased by about a third when the antibiotic is taken with food.
Rifampicin was introduced in 1967, as a major addition to the cocktail-drug treatment of tuberculosis and inactive meningitis, along with pyrazinamide, isoniazid, ethambutol and streptomycin ("PIERS"). It requires a prescription in North America. It must be administered regularly daily for several months without break; otherwise, the risk of drug-resistant tuberculosis is greatly increased. In fact, this is the primary reason it is used in tandem with the three aforementioned drugs, particularly isoniazid. This is also the primary motivation behind directly observed therapy for tuberculosis.
Rifampicin resistance develops quickly during treatment, so monotherapy should not be used to treat these infections — it should be used in combination with other antibiotics.Rifampicin is typically used to treat Mycobacterium infections, including tuberculosis and Hansen's disease. It can be used to treat abscesses, as an uncommon complication of BCG vaccination for tuberculosis.[citation needed]
There is no difference between a three to four month regimen of rifampicin and a six to nine month regimen for preventing active tuberculosis in those with HIV-negative latent tuberculosis. The quality of the evidence was however low.
With multidrug therapy used as the standard treatment of Hansen's disease, rifampicin is always used in combination with dapsone and clofazimine to avoid eliciting drug resistance.

Monday, December 30, 2013

About bicozamycin


The efficacy of bicozamycin, a poorly absorbable antibiotic, in the treatment of acute diarrhea was assessed in a prospective, double-blind study of 140 adults from the United States visiting Guadalajara, Mexico. Patients randomly received bicozamycin (500 mg orally four times daily) or placebo for 3 days. The mean duration of illness was shorter in the bicozamycin than the placebo treatment groups for patients with diarrhea due to Shigella (37 versus 96 hours; p = 0.01), toxigenic Escherichia coli (31 versus 60 hours; p = 0.003), and unknown pathogens (18 versus 41 hours; p = 0.02). Cramps were significantly relieved by bicozamycin in all patients. Treatment failed in significantly fewer patients treated with bicozamycin than those treated with placebo when diarrhea was associated with Shigella, Salmonella or toxigenic E. coli. bicozamycin was well tolerated and appears to be effective therapy for acute travelers' diarrhea of diverse causes. These data show the value of an antibiotic in the therapy of toxigenic E. coli infection and indicate a need to reevaluate the clinical dictum that nonabsorbable antibiotics are ineffective against invasive enteropathogens.
CAS No.:38129-37-2
Synonyms: Aizumycin;Bacteron;Bicyclomycin;
Molecular formula:  C12H18N2O7
MW: 302.281
EINECS: 253-795-3
Mol file: 38129-37-2.mol

What is Mesterolone ?


Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron (as Provironum in Asia-Pacific region), by Bayer Schering Pharma (earlier by Schering). In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and rarely used for replacement therapies
Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.Mesterolone  is widely applied in pharmaceutical, food, health care and other industries.

Sunday, December 29, 2013

about Tadalafil


Tadalafil is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors.
Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide. It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg (two 20-mg tablets) once daily.
Tadalafil is also manufactured and sold under the name of Tadacip by the Indian pharmaceutical company Cipla in doses of 10 mg and 20 mg.

About Mesterolone


Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron (as Provironum in Asia-Pacific region), by Bayer Schering Pharma (earlier by Schering). In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and rarely used for replacement therapies
Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.Mesterolone  is widely applied in pharmaceutical, food, health care and other industries.

Friday, December 27, 2013

Description of Nano gold(Au) powder


Nano gold(Au) powder Description
1. Brown black
2. Particle size: 20-30nm
3. Purity: 99.95%
4. Colorant, antibiotic
Nano gold(Au) powder  Main application field:
1. Colorant in foodstuff, glass and organism.
2. Tarnishproof coloring material.
3. Analysis DNA.
4. Used for the determination of the genetic gene
5. To add into cosmetics can skin whitening, anti-aging, moisturizing and antibiotic.
6. Mixing with TiO2 can be made into environment purification products, especially clear CO such harmful substances and the effects are very good.