Friday, January 24, 2014

what is ferulic acid ?


Ferulic acid is a hydroxycinnamic acid, a type of organic compound. It is an abundant phenolic phytochemical found in plant cell wall components such as arabinoxylans as covalent side chains. It is related to trans-cinnamic acid. As a component of lignin, ferulic acid is a precursor in the manufacture of other aromatic compounds.

Ferulic acid is found in the seeds of coffee, apple, artichoke, peanut, and orange, as well as in both seeds and cell walls of commelinid plants (such as rice, wheat, oats, the Chinese water chestnut (Eleocharis dulcis) and pineapple).
In cereals, ferulic acid is localized in the bran the hard outer layer of grain. In wheat, phenolic compounds are mainly found in the form of insoluble bound ferulic acid and be relevant to resistance to wheat fungal diseases. The highest known concentration of ferulic acid glucoside has been found in flax seed (4.1 +/- 0.2 g). It is also found in barley grain.
Asterid Eudicot plants can also produce ferulic acid   The tea brewed from the leaves of yacón (Smallanthus sonchifolius), a traditionally grown in the Northern and Central Andes, contains quantities of ferulic acid, as well as the tea brewed from the European centaury (Centaurium erythraea), a plant used as a medical herb in many parts of Europe. In legumes, the white bean variety navy bean is the richest source of ferulic acid among the common bean (Phaseolus vulgaris) varieties

what is Testosterone-Decanoate ?

The side-effects of Testosterone-Decanoate will be the same as all testosterone compounds; after all, testosterone is the same hormone regardless of the ester attached. As this is the case, the side-effects of Testosterone-Decanoate will largely surround its strong aromatizing nature; aromatization referring to the conversion of testosterone into estrogen. As estrogen levels increase, if they get too high this can lead to some of the most commonly associated anabolic steroidal side-effects on earth, but thankfully there is hope. Testosterone is one of the best steroids on earth for healthy adult men; not only because of the benefits, but equally important is its high level of toleration; that alone is a massive benefit.

Catalog No: 3B3-004632
CAS No: 5721-91-5
Molecular Formula: C29H46O3
Molecular Weight: 442.67
More about Testosterone-Decanoate

Thursday, January 23, 2014

what is Esomeprazole ?


Esomeprazole is used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole (marketed as Losec/Prilosec), and AstraZeneca claims improved efficacy of this single enantiomer product over the racemic  mixture of omeprazole. However, this greater efficacy has been disputed, with some claiming it offers no benefit from its older form.
 The primary uses of esomeprazole are gastroesophageal reflux disease, treatment and maintenance of erosive esophagitis, treatment of duodenal ulcers caused by H. pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and treatment of gastrointestinal ulcers associated with Crohn's disease.
Esomeprazole is combined with the antibiotics clarithromycin and amoxicillin (or metronidazole in penicillin-hypersensitive patients) in the 7-14 day eradication triple therapy for Helicobacter pylori. Infection by H. pylori is the causative factor in the majority of peptic and duodenal ulcers.

Information about Sodium dichloroacetate


Sodium dichloroacetate has been shown to have numerous effects on pathways of intermediary metabolism. Experiments have reported the compound to inhibit gluconeogenesis and stimulate peripheral glucose utilization. It has additionally been found to facilitate oxidation of lactate via increase in activity of pyruvate dehydrogenase. This agent also demonstrates the ability to inhibit lipogenesis and cholesterolgenesis as well as its own metabolism. Furthermore, assays have found Sodium dichloroacetate to improve cardiac output and left ventricular mechanical efficiency via facilitation of myocardial metabolism of lactate and carbohydrate as opposed to fat. Other studies suggest that Sodium dichloroacetate may decrease proliferation and induce apoptosis in numerous cancer cell lines.
CAS: 2156-56-1
Molecular Formula:C2HCl2NaO2
Formula Weight:150.92
Description:
Melting point:198 ºC (dec.)
Boiling point:194°Cat760mmHg
Flash Point:75.6°C

Wednesday, January 22, 2014

what is Agkistrodon acutus ?


Agkistrodon acutus has a big head, triangle shape. There is a short and upwarp gibbosity formed by rostral and nose scales in rostral part. Head dorsal is blackish-brown, with large symmetrical scales and dimple. Its back  body is nut brown and dark brown, with a large square plaque in the middle of back. Ventral is white, with interlaced patches of dark brown. Its bodily form is short, the longest male 1335 +206 mm, females 1238 +165 mm. 
 It has been long said of medicinal value of Agkistrodon acutus, but as the main drug acutus, specifically for medical research of rheumatoid arthritis has not been the first time. Experts believe that Agkistrodon acutus venom has the function of expelling wind and remiving damness, anticoagulation and antithrombotic, removing fibrin, lower blood viscosity, expansion of blood vessels, improving microcirculation and reduce blood lipids. The medicinal value of Agkistrodon acutus venom is major applications in the treatment of rheumatic diseases.

the description of bicozamycin

The efficacy of bicozamycin, a poorly absorbable antibiotic, in the treatment of acute diarrhea was assessed in a prospective, double-blind study of 140 adults from the United States visiting Guadalajara, Mexico. Patients randomly received bicozamycin (500 mg orally four times daily) or placebo for 3 days. The mean duration of illness was shorter in the bicozamycin than the placebo treatment groups for patients with diarrhea due to Shigella (37 versus 96 hours; p = 0.01), toxigenic Escherichia coli (31 versus 60 hours; p = 0.003), and unknown pathogens (18 versus 41 hours; p = 0.02). Cramps were significantly relieved by bicozamycin in all patients. Treatment failed in significantly fewer patients treated with bicozamycin than those treated with placebo when diarrhea was associated with Shigella, Salmonella or toxigenic E. coli. bicozamycin was well tolerated and appears to be effective therapy for acute travelers' diarrhea of diverse causes. These data show the value of an antibiotic in the therapy of toxigenic E. coli infection and indicate a need to reevaluate the clinical dictum that nonabsorbable antibiotics are ineffective against invasive enteropathogens.

Tuesday, January 21, 2014

Information about Dimethylaminoethanol


Dimethylaminoethanol, also known as dimethylethanolamine (DMAE and DMEA respectively), is a primary alcohol. This compound also goes by the names of N,N-dimethyl-2-aminoethanol, beta-dimethylaminoethyl alcohol, beta-hydroxyethyldimethylamine and Deanol. It is a transparent, pale-yellow liquid.
Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is also used in mass quantities for water treatment, and to some extent in the coatings industry. It is used in the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. It is also an additive to paint removers, boiler water and amino resins. It forms a number of salts with melting points below room temperature (ionic liquids) such as N,N-dimethylethanolammonium acetate and N,N-dimethylethanolammonium octanoate, which have been used as alternatives to conventional solvents.
2-Dimethylaminoethyl chloride hydrochloride is an intermediate made from dimethylaminoethanol that is widely used for the manufacture of pharmaceuticals.
DMAE (Dimethylaminoethanol) is a chemical naturally produced in the human brain. It is thought to be used by the body in converting choline to the neurotransmitter, acetylcholine (i.e., it is a precursor to acetylcholine). This is the basis for thinking that supplementing with DMAE will enhance brain activity.DMAE may also provide some benefit in patients with tardive dyskinesia.
CAS NO:108-01-0 
Molecular formula:C4H11NO
Molecular weight:89.14 g/mol